19. Precursor Chemicals

Nearly every drug requires precursor chemicals in their manufacture. These potentially hazardous chemicals are widely used in legitimate industries, but can be diverted to make drugs, therefore it is important to determine:

  1. the specific precursor found, and
  2. whether the person or company is authorized to handle that precursor.

Your national regulatory agency licences companies authorized to handle precursors.

Many substances look like controlled precursors but legitimate precursors and other chemicals will be marked with an appropriate label identifying potential hazards. Traffickers often mis-declare, mis-label or remove labels from containers making identification difficult — never assume the substance is what a suspect declares. A field test kit is a good way to indicate the presence of a controlled precursor.

Always use gloves, masks and safety goggles when handling chemicals.

Compressed gas
Explosive
Irritant
Corrosive
Frammable
Oxidizing
Environmentally damaging
Health hazard
Toxic

There are 24 precursors currently under international control split into higher (Table I) and lower (Table II) levels of control. The list of chemicals named is not exhaustive.

Table I (Essential Precursors)
1-Phenyl-2-propanone (P-2-P)

Vicious, colorless or pale yellow liquid used in the pharmaceutical industry for legitimate manufacture of amphetamines.

Illicit use: amphetamine / methamphetamine

Other names: Benzyl methyl ketone (BMK)

HS code: 2914 31 00

CAS No.: 103-79-7

3,4-Methylenedioxyphenyl-2- propanone (3,4-MDP-2-P)

A colorless or pale yellow liquid with an odor of aniseed, with almost no known legitimate uses.

Illicit use: MDMA (ecstasy)

Other names: Piperonyl methyl ketone (PMK)

HS code: 2932 92 00

CAS No.: 4676-39-5

Acetic anhydride

A colorless liquid with a very strong vinegar odor, used widely in the manufacture of cellulose acetate, aspirin, brake fluids, dyes and explosives, and in textile bleaching and metal polishing.

Illicit use: heroin and amphetamine/ methamphetamine

Other names: Acetyl acetate

HS code: 2915 24 00

CAS No.: 108-24-7

alpha-Phenylacetoacetonitrile (APAAN)

A white to pale yellow crystalline powder with a slight vague smell of bitter almonds, which has no known legitimate use.

Illicit use: amphetamine / methamphetamine

Other names: 3-oxo-2- phenylbutanenitrile

HS code: 2926 40

CAS No.: 4468-48-8

Ephedrine

A colorless, sometimes white orange yellow fine crystal soapy to the touch, used in herbal supplements.

Illicit use: methamphetamine

Other names: 2-(Methylamino)-1-phenyl-1-propanol

HS code: 2939 41 00

CAS No.: 299-42-3 50-98-6

Herbal supplements containing ephedrine can be used to make methamphetamine.

Ergometrine

Colorless crystals or needles which turn brown when exposed to humidity or light, used in migraine treatment and during child birth (labor) in extremely small amounts.

Illicit use: LSD (Lysergic acid diethylamide)

Other names: ergonovine, lysergic acid, 2-propanolamide

HS code: 2939 61 00

CAS No.: 60-79-7

Ergotamine

Colorless crystals or needles which turn brown when exposed to humidity or light, used in migraine treatment and during childbirth (labor) in extremely small amounts.

Illicit use: LSD (Lysergic acid diethylamide)

Other names: Cafergot®, Ergomar®

HS code: 2939 62 00

CAS No.: 113-15-5

Isosafrole

Vicious, colorless or pale yellow liquid with an odor of aniseed, used in the perfume industry and for manufacture of piperonal.

Illicit use: MDMA (ecstasy)

Other names: 5-(Prop-1-enyl)benzo[d] [1,3]dioxole

HS code: 2932 91 00

CAS No.: 120-58-1

Lysergic acid

White crystals or crystalline powder used in organic synthesis and medical research in very small amounts.

Illicit use: LSD (Lysergic acid diethylamide)

Other names: 7-Methyl-4,6,6a,7,8,9- hexahydroindolo[4,3-fg]quinoline9-carboxylic acid

HS code: 2939 63 00

CAS No.: 82-58-6

N-Acetylanthranilic acid

A fine colorless or white crystalline powder, used in the manufacture of pharmaceutical products, plastics and in fine chemistry

Illicit use: methaqualone

Other names: 2-acetamidobenzoic acid

HS code: 2924 23 00

CAS No.: 89-52-1

Norephedrine

White crystals with a faint odor of benzoic acid, used in the manufacture of nasal decongestants and appetite suppressants.

Illicit use: amphetamine

Other names: Phenylpropanolamine

HS code: 2939 49 00

CAS No.: 14838-15-4

Phenylacetic acid (PAA)

A white to yellow powder with a strong unpleasant sweat or urine odor, used in penicillin manufacture, the flavoring and perfume industry and cleaning solutions.

Illicit use: amphetamine, methamphetamine and 1-Phenyl-2- propanone (P-2-P)

Other names: alpha-toluic acid

HS code: 2916 34 00

CAS No.: 103-82-2

Piperonal

Sparkling colorless needle-shaped crystals with an odor of vanilla and cherry, used in organic synthesis, and the perfume, flavoring and pesticide industries.

Illicit use: MDMA (ecstasy)

Other names: Heliotropin

HS code: 2932 93 00

CAS No.: 120-57-0

Potassium permanganate

Odorless dark violet crystals with a metallic blue sparkle, commonly used in bleaching, disinfectants, anti-bacterial and in water purification.

Illicit use: cocaine, methcathinone

Other names: Chameleon mineral, Cairox®

HS code: 2841 61 00

CAS No.: 7722-64-7

Pseudoephedrine

Odorless white crystalline powder or needle-shaped crystals, used in cold medicines.

Illicit use: methamphetamine

Other names: 2-methylamino-1-phenylpropan-1-ol, Actifed®, Sudafed®

HS code: 2939 42 00

CAS No.: 90-82-4 345-78-8

Cold medicines containing pseudoephedrine can be used to make methamphetamine. Encountering lots of cold medicine tablets is a sign of precursor trafficking.
Safrole

Colorless or slightly yellow liquid or crystals with a pleasant candylike odor, used in the perfume and flavoring (cherry and vanilla) industries and for manufacture of piperonal.

Illicit use: MDMA (ecstasy) and piperonal

Other names: 5-(2-propenyl)-1,3- benzodioxole

HS code: 2932 94 00

CAS No.: 94-59-7

The substance is often found as oils rich in safrole, such as sassafras oil.
Table II (Primarily Acids and Solvents)
Acetone

Very fluid clear colorless volatile liquid with a sharp, faintly aromatic odor, used as a common solvent used for manufacture of lubricants, plastics and paints.

Illicit use: amphetamines, cocaine, heroin, LSD, methaqualone

Other names: 2-propanone

HS code: 2914 11 00

CAS No.: 67-64-1

Anthranilic acid

A white to pale yellow crystalline powder, used in the manufacture of dyes, perfumes and insect repellent.

Illicit use: methaqualone

Other names: 2-aminobenzoic acid

HS code: 2922 43 00

CAS No.: 118-92-3

Ethyl ether

Very fluid colorless volatile liquid with a highly characteristic strong irritating odor, used in the chemical and pharmaceutical industries to extract oils, and in the manufacture of ammunition, plastics and perfumes.

Illicit use: Solvent used in most drug manufacture

Other names: Ethoxyethane, diethyl ether

HS code: 2909 11 00

CAS No.: 60-29-7

Hydrochloric acid

A clear colorless to pale yellow liquid with a strong acrid pungent odor, used in the manufacture of chlorides and hydrochlorides.

Illicit use: Acid used in all drug manufacture

Other names: Muriatic acid

HS code: 2806 10 00

CAS No.: 7647-01-0

Methyl ethyl ketone (MEK)

A clear colorless liquid with a sharp acetone odor, used in the manufacture of solvents and for degreasing.

Illicit use: heroin, cocaine

Other names: Butanone

HS code: 2914 12 00

CAS No.: 78-93-3

Piperidine

A clear colorless liquid with a strong peppery or ammonia odor, used in pharmaceutical industry for anaesthetics and analgesics and in the manufacture of rubber and plastics.

Illicit use: phencyclidine (PCP)

Other names: Hexahydropyridine, azacyclohexane

HS code: 2933 32 00

CAS No.: 110-89-4

Sulphuric acid

A clear viscous, colorless liquid, commonly used in the manufacture fertilizers, industrial explosives, dyes, paper, cleaning agents and batteries.

Illicit use: morphine, cocaine, amphetamines

Other names: Sulfuric acid

HS code: 2807 00

CAS No.: 7664-93-9

Toluene

A clear colorless liquid with a strong benzene odor, used as is a common industrial solvent in the manufacture of benzaldehydes, explosives, dyes and coatings.

Illicit use: amphetamines, cocaine, methaqualone

Other names: Methylbenzene

HS code: 2902 30

CAS No.: 108-88-3